Manganese-Enhanced Magnetic Resonance Imaging for Detection of Vasoactive Intestinal Peptide Receptor 2 Agonist Therapy in a Model of Parkinson’s Disease
Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice.
Enhancement of α-Helix Mimicry by an α/β-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain Array.
Extending foldamer design beyond α-helix mimicry: α/β-peptide inhibitors of vascular endothelial growth factor signaling.
Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain.
Computational design of a β-peptide that targets transmembrane helices.
Shandler SJ, Korendovych IV, Moore DT, Smith-Dupont KB, Streu CN, Litvinov RI, Billings PC, Gai F, Bennett JS, DeGrado WF. J Am Chem Soc. 2011 Aug 17;133(32):12378-81. doi: 10.1021/ja204215f. Epub 2011 Jul 22.
Environment- and sequence-dependence of helical type in membrane-spanning peptides composed of β3-amino acids.
Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design.
Broad Distribution of Energetically Important Contacts across an Extended Protein Interface.
Development of a rotamer library for use in beta-peptide foldamer computational design.
Computational design of a self-assembling β-peptide oligomer.
Structural and biological mimicry of protein surface recognition by α/β-peptide foldamers.
High-resolution structural characterization of a helical α/β-peptide foldamer bound to the anti-apoptotic protein Bcl-xL.
Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly
Sequence-based design of α/β-peptide foldamers that mimic BH3 domains.
Exploration of backbone space in foldamers containing α- and β-amino acid residues: developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-xL.
Foldamers as versatile frameworks for the design and evolution of function.